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Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag

[Image: see text] Homogeneously glycosylated proteins are important targets for fundamental research and for biopharmaceutical development. The use of unnatural protein–glycan linkages bearing structural similarity to their native counterparts can accelerate the synthesis of glycoengineered proteins...

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Detalles Bibliográficos
Autores principales: Hudak, Jason E., Yu, Helen H., Bertozzi, Carolyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187659/
https://www.ncbi.nlm.nih.gov/pubmed/21866965
http://dx.doi.org/10.1021/ja206023e