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Dengue — Quo tu et quo vadis?
Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187692/ https://www.ncbi.nlm.nih.gov/pubmed/21994796 http://dx.doi.org/10.3390/v3091562 |
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author | Chen, Rubing Vasilakis, Nikos |
author_facet | Chen, Rubing Vasilakis, Nikos |
author_sort | Chen, Rubing |
collection | PubMed |
description | Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence. |
format | Online Article Text |
id | pubmed-3187692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31876922011-10-12 Dengue — Quo tu et quo vadis? Chen, Rubing Vasilakis, Nikos Viruses Review Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence. Molecular Diversity Preservation International (MDPI) 2011-09-01 /pmc/articles/PMC3187692/ /pubmed/21994796 http://dx.doi.org/10.3390/v3091562 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Chen, Rubing Vasilakis, Nikos Dengue — Quo tu et quo vadis? |
title | Dengue — Quo tu et quo vadis? |
title_full | Dengue — Quo tu et quo vadis? |
title_fullStr | Dengue — Quo tu et quo vadis? |
title_full_unstemmed | Dengue — Quo tu et quo vadis? |
title_short | Dengue — Quo tu et quo vadis? |
title_sort | dengue — quo tu et quo vadis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187692/ https://www.ncbi.nlm.nih.gov/pubmed/21994796 http://dx.doi.org/10.3390/v3091562 |
work_keys_str_mv | AT chenrubing denguequotuetquovadis AT vasilakisnikos denguequotuetquovadis |