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Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations

Matrix metalloproteinases (MMP) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-apoptotic ligands, and the release and cleavage of cell-surface receptors. Hence, the development of potent and selective inhibitors t...

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Detalles Bibliográficos
Autores principales:	Giangreco, Ilenia, Lattanzi, Gianluca, Nicolotti, Orazio, Catto, Marco, Laghezza, Antonio, Leonetti, Francesco, Stefanachi, Angela, Carotti, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187794/ https://www.ncbi.nlm.nih.gov/pubmed/21998672 http://dx.doi.org/10.1371/journal.pone.0025597

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