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Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States
OBJECTIVE: To investigate the potentially prognostic value of a resting state electroencephalogram (EEG) with regards to the clinical outcome from vegetative and minimally conscious states (VS and MCS) in terms of survival six months after a brain injury. METHODS: We quantified a dynamic repertoire...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187816/ https://www.ncbi.nlm.nih.gov/pubmed/21998732 http://dx.doi.org/10.1371/journal.pone.0025967 |
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author | Fingelkurts, Alexander A. Fingelkurts, Andrew A. Bagnato, Sergio Boccagni, Cristina Galardi, Giuseppe |
author_facet | Fingelkurts, Alexander A. Fingelkurts, Andrew A. Bagnato, Sergio Boccagni, Cristina Galardi, Giuseppe |
author_sort | Fingelkurts, Alexander A. |
collection | PubMed |
description | OBJECTIVE: To investigate the potentially prognostic value of a resting state electroencephalogram (EEG) with regards to the clinical outcome from vegetative and minimally conscious states (VS and MCS) in terms of survival six months after a brain injury. METHODS: We quantified a dynamic repertoire of EEG oscillations in resting condition with eyes closed in patients in VS and MCS. The exact composition of EEG oscillations was assessed by analysing the probability-classification of short-term EEG spectral patterns. RESULTS: Results demonstrated that (a) the diversity and the variability of EEG for Non-Survivors were significantly lower than for Survivors; and (b) a higher probability of mostly delta and slow-theta oscillations occurring either alone or in combination were found during the first assessment for patients with a bad outcome (i.e., those who died) within six months of an injury compared to patients who survived. At the same time, patients with a good outcome (i.e., those who survived) after six months post-injury had a higher probability of mostly fast-theta and alpha oscillations occurring either alone or in combination during the first assessment when compared to patients who died within six months of an injury. CONCLUSIONS: Resting state EEGs properly analysed may have a potentially prognostic value with regards to the outcome from VS or MCS in terms of survival six months after a brain injury. SIGNIFICANCE: This work may have implications for clinical care, rehabilitative programmes and medical–legal decisions for patients with impaired consciousness states after being in a coma due to acute brain injuries. |
format | Online Article Text |
id | pubmed-3187816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31878162011-10-13 Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States Fingelkurts, Alexander A. Fingelkurts, Andrew A. Bagnato, Sergio Boccagni, Cristina Galardi, Giuseppe PLoS One Research Article OBJECTIVE: To investigate the potentially prognostic value of a resting state electroencephalogram (EEG) with regards to the clinical outcome from vegetative and minimally conscious states (VS and MCS) in terms of survival six months after a brain injury. METHODS: We quantified a dynamic repertoire of EEG oscillations in resting condition with eyes closed in patients in VS and MCS. The exact composition of EEG oscillations was assessed by analysing the probability-classification of short-term EEG spectral patterns. RESULTS: Results demonstrated that (a) the diversity and the variability of EEG for Non-Survivors were significantly lower than for Survivors; and (b) a higher probability of mostly delta and slow-theta oscillations occurring either alone or in combination were found during the first assessment for patients with a bad outcome (i.e., those who died) within six months of an injury compared to patients who survived. At the same time, patients with a good outcome (i.e., those who survived) after six months post-injury had a higher probability of mostly fast-theta and alpha oscillations occurring either alone or in combination during the first assessment when compared to patients who died within six months of an injury. CONCLUSIONS: Resting state EEGs properly analysed may have a potentially prognostic value with regards to the outcome from VS or MCS in terms of survival six months after a brain injury. SIGNIFICANCE: This work may have implications for clinical care, rehabilitative programmes and medical–legal decisions for patients with impaired consciousness states after being in a coma due to acute brain injuries. Public Library of Science 2011-10-05 /pmc/articles/PMC3187816/ /pubmed/21998732 http://dx.doi.org/10.1371/journal.pone.0025967 Text en Fingelkurts et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Fingelkurts, Alexander A. Fingelkurts, Andrew A. Bagnato, Sergio Boccagni, Cristina Galardi, Giuseppe Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title | Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title_full | Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title_fullStr | Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title_full_unstemmed | Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title_short | Life or Death: Prognostic Value of a Resting EEG with Regards to Survival in Patients in Vegetative and Minimally Conscious States |
title_sort | life or death: prognostic value of a resting eeg with regards to survival in patients in vegetative and minimally conscious states |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187816/ https://www.ncbi.nlm.nih.gov/pubmed/21998732 http://dx.doi.org/10.1371/journal.pone.0025967 |
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