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Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia
Clofarabine (40 mg/m(2)/day × 5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m(2)/day × 5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (N = 4) and relapsed (N = 17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myelosuppres...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187852/ https://www.ncbi.nlm.nih.gov/pubmed/21455604 http://dx.doi.org/10.1007/s00277-011-1223-2 |
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author | Tse, Eric Leung, Anskar Y. H. Sim, Joycelyn Lee, Harold K. K. Liu, Herman S. Y. Yip, Sze-Fai Kwong, Yok-Lam |
author_facet | Tse, Eric Leung, Anskar Y. H. Sim, Joycelyn Lee, Harold K. K. Liu, Herman S. Y. Yip, Sze-Fai Kwong, Yok-Lam |
author_sort | Tse, Eric |
collection | PubMed |
description | Clofarabine (40 mg/m(2)/day × 5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m(2)/day × 5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (N = 4) and relapsed (N = 17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myelosuppression was observed in all cases, with two patients dying of bacterial sepsis. Nine patients achieved a complete remission. Disease status, number of prior therapies, and cytogenetic aberrations were not associated with the outcome. However, remission was only achieved with Ara-C at 2 g/m(2)/day and not 1 g/m(2)/day (9/15 versus 0/4, P = 0.03). |
format | Online Article Text |
id | pubmed-3187852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31878522011-10-12 Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia Tse, Eric Leung, Anskar Y. H. Sim, Joycelyn Lee, Harold K. K. Liu, Herman S. Y. Yip, Sze-Fai Kwong, Yok-Lam Ann Hematol Original Article Clofarabine (40 mg/m(2)/day × 5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m(2)/day × 5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (N = 4) and relapsed (N = 17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myelosuppression was observed in all cases, with two patients dying of bacterial sepsis. Nine patients achieved a complete remission. Disease status, number of prior therapies, and cytogenetic aberrations were not associated with the outcome. However, remission was only achieved with Ara-C at 2 g/m(2)/day and not 1 g/m(2)/day (9/15 versus 0/4, P = 0.03). Springer-Verlag 2011-04-01 2011 /pmc/articles/PMC3187852/ /pubmed/21455604 http://dx.doi.org/10.1007/s00277-011-1223-2 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Article Tse, Eric Leung, Anskar Y. H. Sim, Joycelyn Lee, Harold K. K. Liu, Herman S. Y. Yip, Sze-Fai Kwong, Yok-Lam Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title | Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title_full | Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title_fullStr | Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title_full_unstemmed | Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title_short | Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
title_sort | clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187852/ https://www.ncbi.nlm.nih.gov/pubmed/21455604 http://dx.doi.org/10.1007/s00277-011-1223-2 |
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