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Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes

We discuss the case of synchronous bilateral lung cancers which feature the same histological phenotype and a different EGFR mutational profile. Both histological and molecular characterizations were performed on specimens derived thorough CT-guided fine needle aspiration. A first-line chemotherapy...

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Autores principales: Stella, Giulia M, Cemmi, Francesca, Inghilleri, Simona, Zorzetto, Michele, Luisetti, Maurizio, Pozzi, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187931/
https://www.ncbi.nlm.nih.gov/pubmed/21980321
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author Stella, Giulia M
Cemmi, Francesca
Inghilleri, Simona
Zorzetto, Michele
Luisetti, Maurizio
Pozzi, Ernesto
author_facet Stella, Giulia M
Cemmi, Francesca
Inghilleri, Simona
Zorzetto, Michele
Luisetti, Maurizio
Pozzi, Ernesto
author_sort Stella, Giulia M
collection PubMed
description We discuss the case of synchronous bilateral lung cancers which feature the same histological phenotype and a different EGFR mutational profile. Both histological and molecular characterizations were performed on specimens derived thorough CT-guided fine needle aspiration. A first-line chemotherapy was unsuccessful. Subsequent objective response to the EGFR inhibitor Erlotinib was clearly coherent with the sequencing data and the mutated nodule was effectively reduced (> 50%) after therapy, while the lesion assessed as EGFR wild type featured a slight response. This report has two relevant implications. It points out that in case of multiple malignant lesions at time of diagnosis, molecular profiling should be as extensive as possible and it might contribute to clarify the association between the lesions found. Besides the molecular analysis on cytology specimens could identify an accurate and safe diagnostic approach for clinical use.
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spelling pubmed-31879312011-10-06 Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes Stella, Giulia M Cemmi, Francesca Inghilleri, Simona Zorzetto, Michele Luisetti, Maurizio Pozzi, Ernesto J Cancer Case Report We discuss the case of synchronous bilateral lung cancers which feature the same histological phenotype and a different EGFR mutational profile. Both histological and molecular characterizations were performed on specimens derived thorough CT-guided fine needle aspiration. A first-line chemotherapy was unsuccessful. Subsequent objective response to the EGFR inhibitor Erlotinib was clearly coherent with the sequencing data and the mutated nodule was effectively reduced (> 50%) after therapy, while the lesion assessed as EGFR wild type featured a slight response. This report has two relevant implications. It points out that in case of multiple malignant lesions at time of diagnosis, molecular profiling should be as extensive as possible and it might contribute to clarify the association between the lesions found. Besides the molecular analysis on cytology specimens could identify an accurate and safe diagnostic approach for clinical use. Ivyspring International Publisher 2011-09-23 /pmc/articles/PMC3187931/ /pubmed/21980321 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Case Report
Stella, Giulia M
Cemmi, Francesca
Inghilleri, Simona
Zorzetto, Michele
Luisetti, Maurizio
Pozzi, Ernesto
Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title_full Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title_fullStr Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title_full_unstemmed Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title_short Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
title_sort synchronous lung cancers: when same histological types feature different molecular profiles and response phenotypes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187931/
https://www.ncbi.nlm.nih.gov/pubmed/21980321
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