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Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

The allosteric mechanism plays a key role in cellular functions of several PDZ domain proteins (PDZs) and is directly linked to pharmaceutical applications; however, it is a challenge to elaborate the nature and extent of these allosteric interactions. One solution to this problem is to explore the...

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Detalles Bibliográficos
Autores principales:	Gerek, Z. Nevin, Ozkan, S. Banu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188487/ https://www.ncbi.nlm.nih.gov/pubmed/21998559 http://dx.doi.org/10.1371/journal.pcbi.1002154

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