Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases

The emerging structural information about allosteric kinase complexes and the growing number of allosteric inhibitors call for a systematic strategy to delineate and classify mechanisms of allosteric regulation and long-range communication that control kinase activity. In this work, we have investig...

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Detalles Bibliográficos
Autores principales: Dixit, Anshuman, Verkhivker, Gennady M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188506/
https://www.ncbi.nlm.nih.gov/pubmed/21998569
http://dx.doi.org/10.1371/journal.pcbi.1002179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188506/
https://www.ncbi.nlm.nih.gov/pubmed/21998569
http://dx.doi.org/10.1371/journal.pcbi.1002179

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