Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

Adult height is a classic polygenic trait of high heritability (h (2) ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discov...

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Detalles Bibliográficos
Autores principales: N'Diaye, Amidou, Chen, Gary K., Palmer, Cameron D., Ge, Bing, Tayo, Bamidele, Mathias, Rasika A., Ding, Jingzhong, Nalls, Michael A., Adeyemo, Adebowale, Adoue, Véronique, Ambrosone, Christine B., Atwood, Larry, Bandera, Elisa V., Becker, Lewis C., Berndt, Sonja I., Bernstein, Leslie, Blot, William J., Boerwinkle, Eric, Britton, Angela, Casey, Graham, Chanock, Stephen J., Demerath, Ellen, Deming, Sandra L., Diver, W. Ryan, Fox, Caroline, Harris, Tamara B., Hernandez, Dena G., Hu, Jennifer J., Ingles, Sue A., John, Esther M., Johnson, Craig, Keating, Brendan, Kittles, Rick A., Kolonel, Laurence N., Kritchevsky, Stephen B., Le Marchand, Loic, Lohman, Kurt, Liu, Jiankang, Millikan, Robert C., Murphy, Adam, Musani, Solomon, Neslund-Dudas, Christine, North, Kari E., Nyante, Sarah, Ogunniyi, Adesola, Ostrander, Elaine A., Papanicolaou, George, Patel, Sanjay, Pettaway, Curtis A., Press, Michael F., Redline, Susan, Rodriguez-Gil, Jorge L., Rotimi, Charles, Rybicki, Benjamin A., Salako, Babatunde, Schreiner, Pamela J., Signorello, Lisa B., Singleton, Andrew B., Stanford, Janet L., Stram, Alex H., Stram, Daniel O., Strom, Sara S., Suktitipat, Bhoom, Thun, Michael J., Witte, John S., Yanek, Lisa R., Ziegler, Regina G., Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M., Zonderman, Alan B., Evans, Michele K., Liu, Yongmei, Becker, Diane M., Cooper, Richard S., Pastinen, Tomi, Henderson, Brian E., Hirschhorn, Joel N., Lettre, Guillaume, Haiman, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188544/
https://www.ncbi.nlm.nih.gov/pubmed/21998595
http://dx.doi.org/10.1371/journal.pgen.1002298

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