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Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mouse with reduced fasting plasma insulin and elevated...

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Detalles Bibliográficos
Autores principales:	Bhatnagar, Sushant, Oler, Angie T., Rabaglia, Mary E., Stapleton, Donald S., Schueler, Kathryn L., Truchan, Nathan A., Worzella, Sara L., Stoehr, Jonathan P., Clee, Susanne M., Yandell, Brian S., Keller, Mark P., Thurmond, Debbie C., Attie, Alan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188574/ https://www.ncbi.nlm.nih.gov/pubmed/21998599 http://dx.doi.org/10.1371/journal.pgen.1002323

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