Microglia in the normally aged hippocampus

The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous sys...

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Detalles Bibliográficos
Autores principales: Choi, Jung Hoon, Won, Moo-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188724/
https://www.ncbi.nlm.nih.gov/pubmed/21998606
http://dx.doi.org/10.5625/lar.2011.27.3.181
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author Choi, Jung Hoon
Won, Moo-Ho
author_facet Choi, Jung Hoon
Won, Moo-Ho
author_sort Choi, Jung Hoon
collection PubMed
description The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morphological changes of the hippocampus have been closely related to microglial changes during normal aging with or without disease. Therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain.
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spelling pubmed-31887242011-10-13 Microglia in the normally aged hippocampus Choi, Jung Hoon Won, Moo-Ho Lab Anim Res Review The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morphological changes of the hippocampus have been closely related to microglial changes during normal aging with or without disease. Therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain. Korean Association for Laboratory Animal Science 2011-09 2011-09-30 /pmc/articles/PMC3188724/ /pubmed/21998606 http://dx.doi.org/10.5625/lar.2011.27.3.181 Text en Copyright © 2011 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Choi, Jung Hoon
Won, Moo-Ho
Microglia in the normally aged hippocampus
title Microglia in the normally aged hippocampus
title_full Microglia in the normally aged hippocampus
title_fullStr Microglia in the normally aged hippocampus
title_full_unstemmed Microglia in the normally aged hippocampus
title_short Microglia in the normally aged hippocampus
title_sort microglia in the normally aged hippocampus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188724/
https://www.ncbi.nlm.nih.gov/pubmed/21998606
http://dx.doi.org/10.5625/lar.2011.27.3.181
work_keys_str_mv AT choijunghoon microgliainthenormallyagedhippocampus
AT wonmooho microgliainthenormallyagedhippocampus

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