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Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse

An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed in the right femur. Lesions were poorly marginated, associated with destruction of the cancellous and cortical elements...

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Autores principales: Hong, Sunhwa, Lee, Hyun-A, Choe, Ohmok, Chung, Youngho, Kim, Okjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188733/
https://www.ncbi.nlm.nih.gov/pubmed/21998615
http://dx.doi.org/10.5625/lar.2011.27.3.251
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author Hong, Sunhwa
Lee, Hyun-A
Choe, Ohmok
Chung, Youngho
Kim, Okjin
author_facet Hong, Sunhwa
Lee, Hyun-A
Choe, Ohmok
Chung, Youngho
Kim, Okjin
author_sort Hong, Sunhwa
collection PubMed
description An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed in the right femur. Lesions were poorly marginated, associated with destruction of the cancellous and cortical elements of the bone, and showed ossification within the soft tissue component. Histologically, the tumor was identified as a poorly differentiated sarcoma. Histopathologic examination of the bone masses revealed invasive proliferation of poorly differentiated neoplastic mesenchymal cells forming streams, bundles, and nests, which resulted in destruction of normal bone. Neoplastic cells exhibited random variation in cellular appearance and arrangement, as well as matrix composition and abundance. Haphazard and often intermingling patterns of osteogenic, chondroblastic, lipoblastic, and angiogenic tissues were present. Larger areas of neoplastic bone and hyaline cartilage contained multiple large areas of hemorrhage and necrosis bordered by neoplastic cells. The mass was diagnosed as an osteosarcoma. To our knowledge, this is the first spontaneous osteosarcoma in an NOD mouse.
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spelling pubmed-31887332011-10-13 Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse Hong, Sunhwa Lee, Hyun-A Choe, Ohmok Chung, Youngho Kim, Okjin Lab Anim Res Case Report An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed in the right femur. Lesions were poorly marginated, associated with destruction of the cancellous and cortical elements of the bone, and showed ossification within the soft tissue component. Histologically, the tumor was identified as a poorly differentiated sarcoma. Histopathologic examination of the bone masses revealed invasive proliferation of poorly differentiated neoplastic mesenchymal cells forming streams, bundles, and nests, which resulted in destruction of normal bone. Neoplastic cells exhibited random variation in cellular appearance and arrangement, as well as matrix composition and abundance. Haphazard and often intermingling patterns of osteogenic, chondroblastic, lipoblastic, and angiogenic tissues were present. Larger areas of neoplastic bone and hyaline cartilage contained multiple large areas of hemorrhage and necrosis bordered by neoplastic cells. The mass was diagnosed as an osteosarcoma. To our knowledge, this is the first spontaneous osteosarcoma in an NOD mouse. Korean Association for Laboratory Animal Science 2011-09 2011-09-30 /pmc/articles/PMC3188733/ /pubmed/21998615 http://dx.doi.org/10.5625/lar.2011.27.3.251 Text en Copyright © 2011 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hong, Sunhwa
Lee, Hyun-A
Choe, Ohmok
Chung, Youngho
Kim, Okjin
Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title_full Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title_fullStr Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title_full_unstemmed Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title_short Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
title_sort spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188733/
https://www.ncbi.nlm.nih.gov/pubmed/21998615
http://dx.doi.org/10.5625/lar.2011.27.3.251
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