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Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia
INTRODUCTION: Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined. Patients with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the signi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188784/ https://www.ncbi.nlm.nih.gov/pubmed/21531705 http://dx.doi.org/10.1136/jnnp.2010.235473 |
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author | Mahoney, Colin J Rohrer, Jonathan D Goll, Johanna C Fox, Nick C Rossor, Martin N Warren, Jason D |
author_facet | Mahoney, Colin J Rohrer, Jonathan D Goll, Johanna C Fox, Nick C Rossor, Martin N Warren, Jason D |
author_sort | Mahoney, Colin J |
collection | PubMed |
description | INTRODUCTION: Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined. Patients with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the significance and basis for these symptoms have not been elucidated. METHODS: 43 patients with a diagnosis of SemD attending a specialist cognitive disorders clinic were retrospectively studied. 14 patients (32% of the cohort) reported at least moderately severe chronic auditory symptoms: seven had tinnitus and a further seven had hyperacusis, and all had brain MRI while symptomatic. MRI data from SemD patients with and without auditory symptoms were compared using voxel based morphometry in order to identify neuroanatomical associations of tinnitus and hyperacusis. RESULTS: Compared with SemD patients with no history of auditory symptoms, patients with tinnitus or hyperacusis had relative preservation of grey matter in the posterior superior temporal lobe and reduced grey matter in the orbitofrontal cortex and medial geniculate nucleus. CONCLUSIONS: Tinnitus and hyperacusis may be a significant issue in SemD. Neuroanatomical evidence in SemD supports previous work implicating a distributed cortico-subcortical auditory and limbic network in the pathogenesis of these abnormal auditory percepts. |
format | Online Article Text |
id | pubmed-3188784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-31887842011-10-13 Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia Mahoney, Colin J Rohrer, Jonathan D Goll, Johanna C Fox, Nick C Rossor, Martin N Warren, Jason D J Neurol Neurosurg Psychiatry Research Paper INTRODUCTION: Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined. Patients with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the significance and basis for these symptoms have not been elucidated. METHODS: 43 patients with a diagnosis of SemD attending a specialist cognitive disorders clinic were retrospectively studied. 14 patients (32% of the cohort) reported at least moderately severe chronic auditory symptoms: seven had tinnitus and a further seven had hyperacusis, and all had brain MRI while symptomatic. MRI data from SemD patients with and without auditory symptoms were compared using voxel based morphometry in order to identify neuroanatomical associations of tinnitus and hyperacusis. RESULTS: Compared with SemD patients with no history of auditory symptoms, patients with tinnitus or hyperacusis had relative preservation of grey matter in the posterior superior temporal lobe and reduced grey matter in the orbitofrontal cortex and medial geniculate nucleus. CONCLUSIONS: Tinnitus and hyperacusis may be a significant issue in SemD. Neuroanatomical evidence in SemD supports previous work implicating a distributed cortico-subcortical auditory and limbic network in the pathogenesis of these abnormal auditory percepts. BMJ Group 2011-04-28 2011-11 /pmc/articles/PMC3188784/ /pubmed/21531705 http://dx.doi.org/10.1136/jnnp.2010.235473 Text en © 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Research Paper Mahoney, Colin J Rohrer, Jonathan D Goll, Johanna C Fox, Nick C Rossor, Martin N Warren, Jason D Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title | Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title_full | Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title_fullStr | Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title_full_unstemmed | Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title_short | Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
title_sort | structural neuroanatomy of tinnitus and hyperacusis in semantic dementia |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188784/ https://www.ncbi.nlm.nih.gov/pubmed/21531705 http://dx.doi.org/10.1136/jnnp.2010.235473 |
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