Dating the age of admixture via wavelet transform analysis of genome-wide data

We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human popu...

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Detalles Bibliográficos
Autores principales: Pugach, Irina, Matveyev, Rostislav, Wollstein, Andreas, Kayser, Manfred, Stoneking, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188801/
https://www.ncbi.nlm.nih.gov/pubmed/21352535
http://dx.doi.org/10.1186/gb-2011-12-2-r19
Descripción
Sumario:We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human populations. The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species.

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