Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck

BACKGROUND: Lapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and human EGFR-2 (HER-2) tyrosine kinases. This study investigated the pharmacodynamic and clinical effects of lapatinib in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). METHOD...

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Detalles Bibliográficos
Autores principales: del Campo, J M, Hitt, R, Sebastian, P, Carracedo, C, Lokanatha, D, Bourhis, J, Temam, S, Cupissol, D, De Raucourt, D, Maroudias, N, Nutting, C M, Compton, N, Midwinter, D, Downie, L, Biswas-Baldwin, N, El-Hariry, I, Harrington, K J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188940/
https://www.ncbi.nlm.nih.gov/pubmed/21829197
http://dx.doi.org/10.1038/bjc.2011.237

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