Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for...

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Autores principales: Sutcliffe, S, Nevin, R L, Pakpahan, R, Elliott, D J, Cole, S R, De Marzo, A M, Gaydos, C A, Isaacs, W B, Nelson, W G, Sokoll, L J, Zenilman, J M, Cersovsky, S B, Platz, E A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188942/
https://www.ncbi.nlm.nih.gov/pubmed/21792196
http://dx.doi.org/10.1038/bjc.2011.271
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author Sutcliffe, S
Nevin, R L
Pakpahan, R
Elliott, D J
Cole, S R
De Marzo, A M
Gaydos, C A
Isaacs, W B
Nelson, W G
Sokoll, L J
Zenilman, J M
Cersovsky, S B
Platz, E A
author_facet Sutcliffe, S
Nevin, R L
Pakpahan, R
Elliott, D J
Cole, S R
De Marzo, A M
Gaydos, C A
Isaacs, W B
Nelson, W G
Sokoll, L J
Zenilman, J M
Cersovsky, S B
Platz, E A
author_sort Sutcliffe, S
collection PubMed
description BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. RESULTS: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (⩾40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively). CONCLUSION: Chlamydia and gonorrhoea may infect the prostate of some infected men.
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spelling pubmed-31889422012-08-23 Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration Sutcliffe, S Nevin, R L Pakpahan, R Elliott, D J Cole, S R De Marzo, A M Gaydos, C A Isaacs, W B Nelson, W G Sokoll, L J Zenilman, J M Cersovsky, S B Platz, E A Br J Cancer Short Communication BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. RESULTS: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (⩾40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively). CONCLUSION: Chlamydia and gonorrhoea may infect the prostate of some infected men. Nature Publishing Group 2011-08-23 2011-07-26 /pmc/articles/PMC3188942/ /pubmed/21792196 http://dx.doi.org/10.1038/bjc.2011.271 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Sutcliffe, S
Nevin, R L
Pakpahan, R
Elliott, D J
Cole, S R
De Marzo, A M
Gaydos, C A
Isaacs, W B
Nelson, W G
Sokoll, L J
Zenilman, J M
Cersovsky, S B
Platz, E A
Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title_full Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title_fullStr Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title_full_unstemmed Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title_short Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
title_sort prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188942/
https://www.ncbi.nlm.nih.gov/pubmed/21792196
http://dx.doi.org/10.1038/bjc.2011.271
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