Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

BACKGROUND: Memory deficits in Alzheimer's disease (AD) manifest together with the loss of synapses caused by the disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines. However, the underlying molecular mechanisms remain elusive. Since it was s...

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Detalles Bibliográficos
Autores principales: Grabrucker, Andreas M, Schmeisser, Michael J, Udvardi, Patrick T, Arons, Magali, Schoen, Michael, Woodling, Nathaniel S, Andreasson, Katrin I, Hof, Patrick R, Buxbaum, Joseph D, Garner, Craig C, Boeckers, Tobias M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189132/
https://www.ncbi.nlm.nih.gov/pubmed/21939532
http://dx.doi.org/10.1186/1750-1326-6-65

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