Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia

BACKGROUND: Although current chemotherapy regimens have remarkably improved the cure rate of pediatric acute promyelocytic leukemia (APL) over the past decade, more than 20% of patients still die of the disease, and the 5-year cumulative incidence of relapse is 17%. The precise gene pathways that ex...

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Detalles Bibliográficos
Autores principales: Zhang, Hua, Luo, Xue-Qun, Feng, Dan-Dan, Zhang, Xing-Ju, Wu, Jun, Zheng, Yu-Sheng, Chen, Xiao, Xu, Ling, Chen, Yue-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189170/
https://www.ncbi.nlm.nih.gov/pubmed/21880154
http://dx.doi.org/10.1186/1476-4598-10-108

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