Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuro...

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Detalles Bibliográficos
Autores principales: Jeong, Suh Young, Crooks, Daniel R., Wilson-Ollivierre, Hayden, Ghosh, Manik C., Sougrat, Rachid, Lee, Jaekwon, Cooperman, Sharon, Mitchell, James B., Beaumont, Carole, Rouault, Tracey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189198/
https://www.ncbi.nlm.nih.gov/pubmed/22003390
http://dx.doi.org/10.1371/journal.pone.0025404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189198/
https://www.ncbi.nlm.nih.gov/pubmed/22003390
http://dx.doi.org/10.1371/journal.pone.0025404

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