Cargando…

HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K(+) Currents

Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-gated potassium (Kv) channels play an important rol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lina, Liu, Jianuo, Xu, Changshui, Keblesh, James, Zang, Weijin, Xiong, Huangui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189248/ https://www.ncbi.nlm.nih.gov/pubmed/22016798 http://dx.doi.org/10.1371/journal.pone.0025994

Ejemplares similares

HIV-1 Tat Protein Increases Microglial Outward K(+) Current and Resultant Neurotoxic Activity
por: Liu, Jianuo, et al.
Publicado: (2013)

Methamphetamine augments HIV-1 gp120 inhibition of synaptic transmission and plasticity in rat hippocampal slices: Implications for methamphetamine exacerbation of HIV-associated neurocognitive disorders
por: Zheng, Ya, et al.
Publicado: (2022)

Two functionally distinct 4-aminopyridine-sensitive outward K+ currents in rat atrial myocytes
Publicado: (1992)

4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibers
Publicado: (1979)

GABA(B) receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro
por: Cattani, Adriano, et al.
Publicado: (2023)

The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications
por: Dutta, Debashis, et al.
Publicado: (2023)

HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma
por: López, Sheila N., et al.
Publicado: (2017)

Curcumin Protects Microglia and Primary Rat Cortical Neurons against HIV-1 gp120-Mediated Inflammation and Apoptosis
por: Guo, Luyan, et al.
Publicado: (2013)

Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders
por: Liu, Han, et al.
Publicado: (2016)

Effects of 4-aminopyridine on potassium currents in a molluscan neuron
Publicado: (1981)

The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use- dependent block by 4-aminopyridine
Publicado: (1993)

Helix-A peptide prevents gp120-mediated neuronal loss
por: Avdoshina, Valeria, et al.
Publicado: (2019)

ASPP2 Plays a Dual Role in gp120-Induced Autophagy and Apoptosis of Neuroblastoma Cells
por: Liu, Zhiying, et al.
Publicado: (2017)

Macrophage–sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity(‡)
por: Moss, P. J., et al.
Publicado: (2015)

Na(+)-activated K(+) channels express a large delayed outward current in neurons during normal physiology
por: Budelli, Gonzalo, et al.
Publicado: (2009)

Aminopyridine block of transient potassium current
Publicado: (1982)

Effect of naringin on gp120-induced injury mediated by P2X(7) receptors in rat primary cultured microglia
por: Chen, Qiang, et al.
Publicado: (2017)

ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons
por: Liu, Zhiying, et al.
Publicado: (2016)

Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation
por: Zhang, Jingdong, et al.
Publicado: (2021)

Sustained K(+) Outward Currents are Sensitive to Intracellular Heteropodatoxin2 in CA1 Neurons of Organotypic Cultured Hippocampi of Rats
por: Jung, Sung-Cherl, et al.
Publicado: (2012)

The Outward Mindset
por: The Arbinger Institute
Publicado: (2019)

Physiological Corticosterone Attenuates gp120-Mediated Microglial Activation and Is Associated with Reduced Anxiety-Like Behavior in gp120-Expressing Mice
por: Moss, Emaya M., et al.
Publicado: (2023)

Inverse Modulation of Neuronal K(v)12.1 and K(v)11.1 Channels by 4-Aminopyridine and NS1643
por: Dierich, Marlen, et al.
Publicado: (2018)

Eliciting neutralizing antibodies with gp120 outer domain
por: Qin, Y, et al.
Publicado: (2012)

Internalization and Axonal Transport of the HIV Glycoprotein gp120
por: Berth, Sarah, et al.
Publicado: (2015)

Calcium-induced Transitions between the Spontaneous Miniature Outward and the Transient Outward Currents in Retinal Amacrine Cells
por: Mitra, Pratip, et al.
Publicado: (2002)

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity
por: Drummer, Heidi E., et al.
Publicado: (2013)

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
Publicado: (1992)

Human Immunodeficiency Virus Envelope Protein Gp120 Induces Proliferation but Not Apoptosis in Osteoblasts at Physiologic Concentrations
por: Cummins, Nathan W., et al.
Publicado: (2011)

Christmas "Outward and Visible"
Publicado: (1889)

Outward Luxation of the Femur
por: Wyman, W. E. A.
Publicado: (1897)

Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 ± IL-15
por: McKee, Hayley J, et al.
Publicado: (2004)

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41
por: Pu, Jing, et al.
Publicado: (2019)

Convergent HIV-1 Evolution upon Targeted Destabilization of the gp120-gp41 Interface
por: Torrents de la Peña, Alba, et al.
Publicado: (2021)

Neuroprotective Properties of 4-Aminopyridine
por: Dietrich, Michael, et al.
Publicado: (2021)

NMR spectroscopy of HIV-1 gp120 outer domain
por: Sastry, M, et al.
Publicado: (2012)

Behavioral Evidence for a Tau and HIV-gp120 Interaction
por: Vijayan, Murali, et al.
Publicado: (2022)

Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides
por: Kassler, Kristin, et al.
Publicado: (2011)

HIV Subtypes B and C gp120 and Methamphetamine Interaction: Dopaminergic System Implicates Differential Neuronal Toxicity
por: Samikkannu, Thangavel, et al.
Publicado: (2015)

The Protective Effects of IGF-1 on Different Subpopulations of DRG Neurons with Neurotoxicity Induced by gp120 and Dideoxycytidine In Vitro
por: Lu, Lin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_f41jqun6fpse9g73rp2p5oujkg