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Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-ta...

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Detalles Bibliográficos
Autores principales:	Collin, Frédéric, Karkare, Shantanu, Maxwell, Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Mini-Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189412/ https://www.ncbi.nlm.nih.gov/pubmed/21904817 http://dx.doi.org/10.1007/s00253-011-3557-z

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