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Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison

EXPAREL (bupivacaine extended-release liposome injection), DepoFoam bupivacaine, is in development for prolonged postsurgical analgesia. Repeat-dose toxicity studies were conducted in rabbits and dogs to compare the potential local and systemic toxicities of EXPAREL and bupivacaine HCl (Bsol), and t...

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Detalles Bibliográficos
Autores principales:	Richard, Brigitte M., Rickert, Douglas E., Newton, Paul E., Ott, Laura R., Haan, Dean, Brubaker, Abram N., Cole, Phaedra I., Ross, Paul E., Rebelatto, Marlon C., Nelson, Keith G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189577/ https://www.ncbi.nlm.nih.gov/pubmed/22013534 http://dx.doi.org/10.1155/2011/467429

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