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Erythroblast Enucleation

Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, lik...

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Autores principales: Keerthivasan, Ganesan, Wickrema, Amittha, Crispino, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189604/
https://www.ncbi.nlm.nih.gov/pubmed/22007239
http://dx.doi.org/10.4061/2011/139851
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author Keerthivasan, Ganesan
Wickrema, Amittha
Crispino, John D.
author_facet Keerthivasan, Ganesan
Wickrema, Amittha
Crispino, John D.
author_sort Keerthivasan, Ganesan
collection PubMed
description Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half the size of erythrocytes. Recently, there have been many advances in our understanding of the mechanisms underlying mammalian erythrocyte enucleation. This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells.
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spelling pubmed-31896042011-10-17 Erythroblast Enucleation Keerthivasan, Ganesan Wickrema, Amittha Crispino, John D. Stem Cells Int Review Article Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half the size of erythrocytes. Recently, there have been many advances in our understanding of the mechanisms underlying mammalian erythrocyte enucleation. This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells. SAGE-Hindawi Access to Research 2011 2011-10-05 /pmc/articles/PMC3189604/ /pubmed/22007239 http://dx.doi.org/10.4061/2011/139851 Text en Copyright © 2011 Ganesan Keerthivasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Keerthivasan, Ganesan
Wickrema, Amittha
Crispino, John D.
Erythroblast Enucleation
title Erythroblast Enucleation
title_full Erythroblast Enucleation
title_fullStr Erythroblast Enucleation
title_full_unstemmed Erythroblast Enucleation
title_short Erythroblast Enucleation
title_sort erythroblast enucleation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189604/
https://www.ncbi.nlm.nih.gov/pubmed/22007239
http://dx.doi.org/10.4061/2011/139851
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