Cargando…
Erythroblast Enucleation
Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, lik...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189604/ https://www.ncbi.nlm.nih.gov/pubmed/22007239 http://dx.doi.org/10.4061/2011/139851 |
_version_ | 1782213488627679232 |
---|---|
author | Keerthivasan, Ganesan Wickrema, Amittha Crispino, John D. |
author_facet | Keerthivasan, Ganesan Wickrema, Amittha Crispino, John D. |
author_sort | Keerthivasan, Ganesan |
collection | PubMed |
description | Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half the size of erythrocytes. Recently, there have been many advances in our understanding of the mechanisms underlying mammalian erythrocyte enucleation. This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells. |
format | Online Article Text |
id | pubmed-3189604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31896042011-10-17 Erythroblast Enucleation Keerthivasan, Ganesan Wickrema, Amittha Crispino, John D. Stem Cells Int Review Article Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half the size of erythrocytes. Recently, there have been many advances in our understanding of the mechanisms underlying mammalian erythrocyte enucleation. This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells. SAGE-Hindawi Access to Research 2011 2011-10-05 /pmc/articles/PMC3189604/ /pubmed/22007239 http://dx.doi.org/10.4061/2011/139851 Text en Copyright © 2011 Ganesan Keerthivasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Keerthivasan, Ganesan Wickrema, Amittha Crispino, John D. Erythroblast Enucleation |
title | Erythroblast Enucleation |
title_full | Erythroblast Enucleation |
title_fullStr | Erythroblast Enucleation |
title_full_unstemmed | Erythroblast Enucleation |
title_short | Erythroblast Enucleation |
title_sort | erythroblast enucleation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189604/ https://www.ncbi.nlm.nih.gov/pubmed/22007239 http://dx.doi.org/10.4061/2011/139851 |
work_keys_str_mv | AT keerthivasanganesan erythroblastenucleation AT wickremaamittha erythroblastenucleation AT crispinojohnd erythroblastenucleation |