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Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189620/ https://www.ncbi.nlm.nih.gov/pubmed/22007240 http://dx.doi.org/10.4061/2011/619583 |
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author | Dey, Dilip Evans, Gregory R. D. |
author_facet | Dey, Dilip Evans, Gregory R. D. |
author_sort | Dey, Dilip |
collection | PubMed |
description | During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed. |
format | Online Article Text |
id | pubmed-3189620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31896202011-10-17 Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming Dey, Dilip Evans, Gregory R. D. Stem Cells Int Review Article During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed. SAGE-Hindawi Access to Research 2011 2011-10-05 /pmc/articles/PMC3189620/ /pubmed/22007240 http://dx.doi.org/10.4061/2011/619583 Text en Copyright © 2011 D. Dey and G. R. D. Evans. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dey, Dilip Evans, Gregory R. D. Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title_full | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title_fullStr | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title_full_unstemmed | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title_short | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
title_sort | generation of induced pluripotent stem (ips) cells by nuclear reprogramming |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189620/ https://www.ncbi.nlm.nih.gov/pubmed/22007240 http://dx.doi.org/10.4061/2011/619583 |
work_keys_str_mv | AT deydilip generationofinducedpluripotentstemipscellsbynuclearreprogramming AT evansgregoryrd generationofinducedpluripotentstemipscellsbynuclearreprogramming |