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Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming

During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissu...

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Detalles Bibliográficos
Autores principales: Dey, Dilip, Evans, Gregory R. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189620/
https://www.ncbi.nlm.nih.gov/pubmed/22007240
http://dx.doi.org/10.4061/2011/619583
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author Dey, Dilip
Evans, Gregory R. D.
author_facet Dey, Dilip
Evans, Gregory R. D.
author_sort Dey, Dilip
collection PubMed
description During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed.
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spelling pubmed-31896202011-10-17 Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming Dey, Dilip Evans, Gregory R. D. Stem Cells Int Review Article During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed. SAGE-Hindawi Access to Research 2011 2011-10-05 /pmc/articles/PMC3189620/ /pubmed/22007240 http://dx.doi.org/10.4061/2011/619583 Text en Copyright © 2011 D. Dey and G. R. D. Evans. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dey, Dilip
Evans, Gregory R. D.
Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title_full Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title_fullStr Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title_full_unstemmed Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title_short Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
title_sort generation of induced pluripotent stem (ips) cells by nuclear reprogramming
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189620/
https://www.ncbi.nlm.nih.gov/pubmed/22007240
http://dx.doi.org/10.4061/2011/619583
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