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The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer
Abnormalities of chromosome 17 are important molecular genetic events in human breast cancers. Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17. We searched the literature on HER2,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189742/ https://www.ncbi.nlm.nih.gov/pubmed/22016618 http://dx.doi.org/10.3390/ijms12095672 |
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author | Zhang, Wei Yu, Yingyan |
author_facet | Zhang, Wei Yu, Yingyan |
author_sort | Zhang, Wei |
collection | PubMed |
description | Abnormalities of chromosome 17 are important molecular genetic events in human breast cancers. Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17. We searched the literature on HER2, TOP2A, TAU, RDM1, p53, BRCA1 and HIC-1 on the Pubmed database. The association of genes with chromosome 17, biological functions and potential significance are reviewed. In breast cancer, the polysomy 17 (three or more) is the predominant numerical aberration. HER2 amplification is widely utilized as molecular markers for trastuzumab target treatment. Amplified TOP2A, TAU and RDM1 genes are related to a significant response to anthracycline-based chemotherapy, taxane or cisplatin, respectively. In contrast, p53, BRCA1 and HIC-1 are important tumor suppressor genes related to breast carcinogenesis. This review focused on several crucial molecular markers residing on chromosome 17. The authors consider the somatic aberrations of chromosome 17 and associated genes in breast cancer. |
format | Online Article Text |
id | pubmed-3189742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31897422011-10-20 The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer Zhang, Wei Yu, Yingyan Int J Mol Sci Review Abnormalities of chromosome 17 are important molecular genetic events in human breast cancers. Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17. We searched the literature on HER2, TOP2A, TAU, RDM1, p53, BRCA1 and HIC-1 on the Pubmed database. The association of genes with chromosome 17, biological functions and potential significance are reviewed. In breast cancer, the polysomy 17 (three or more) is the predominant numerical aberration. HER2 amplification is widely utilized as molecular markers for trastuzumab target treatment. Amplified TOP2A, TAU and RDM1 genes are related to a significant response to anthracycline-based chemotherapy, taxane or cisplatin, respectively. In contrast, p53, BRCA1 and HIC-1 are important tumor suppressor genes related to breast carcinogenesis. This review focused on several crucial molecular markers residing on chromosome 17. The authors consider the somatic aberrations of chromosome 17 and associated genes in breast cancer. Molecular Diversity Preservation International (MDPI) 2011-09-05 /pmc/articles/PMC3189742/ /pubmed/22016618 http://dx.doi.org/10.3390/ijms12095672 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zhang, Wei Yu, Yingyan The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title | The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title_full | The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title_fullStr | The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title_full_unstemmed | The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title_short | The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer |
title_sort | important molecular markers on chromosome 17 and their clinical impact in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189742/ https://www.ncbi.nlm.nih.gov/pubmed/22016618 http://dx.doi.org/10.3390/ijms12095672 |
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