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Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer

We report a rare case of multiple myeloma with biclonal gammopathy (IgG kappa and IgA lambda type) in a 58-year-old man with prostate cancer who presented with lower back pain. Through computed tomography (CT) imaging, an osteolytic lesion at the L3 vertebra and an enhancing lesion of the prostate g...

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Autores principales: Kim, Nae Yu, Gong, Soo Jung, Kim, Jimyung, Youn, Seon Min, Lee, Jung-Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190009/
https://www.ncbi.nlm.nih.gov/pubmed/22016684
http://dx.doi.org/10.3343/kjlm.2011.31.4.285
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author Kim, Nae Yu
Gong, Soo Jung
Kim, Jimyung
Youn, Seon Min
Lee, Jung-Ae
author_facet Kim, Nae Yu
Gong, Soo Jung
Kim, Jimyung
Youn, Seon Min
Lee, Jung-Ae
author_sort Kim, Nae Yu
collection PubMed
description We report a rare case of multiple myeloma with biclonal gammopathy (IgG kappa and IgA lambda type) in a 58-year-old man with prostate cancer who presented with lower back pain. Through computed tomography (CT) imaging, an osteolytic lesion at the L3 vertebra and an enhancing lesion of the prostate gland with multiple lymphadenopathies were found. In the whole body positron emission tomography-computed tomography (PET-CT), an additional osteoblastic bone lesion was found in the left ischial bone. A prostate biopsy was performed, and adenocarcinoma was confirmed. Decompression surgery of the L3 vertebra was conducted, and the pathologic result indicated that the lesion was a plasma cell neoplasm. Immunofixation electrophoresis showed the presence of biclonal gammopathy (IgG kappa and IgA lambda). Bone marrow plasma cells (CD138 positive cells) comprised 7.2% of nucleated cells and showed kappa positivity. We started radiation therapy for the L3 vertebra lesion, with a total dose of 3,940 cGy, and androgen deprivation therapy as treatment for the prostate cancer.
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spelling pubmed-31900092011-10-20 Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer Kim, Nae Yu Gong, Soo Jung Kim, Jimyung Youn, Seon Min Lee, Jung-Ae Korean J Lab Med Case Report We report a rare case of multiple myeloma with biclonal gammopathy (IgG kappa and IgA lambda type) in a 58-year-old man with prostate cancer who presented with lower back pain. Through computed tomography (CT) imaging, an osteolytic lesion at the L3 vertebra and an enhancing lesion of the prostate gland with multiple lymphadenopathies were found. In the whole body positron emission tomography-computed tomography (PET-CT), an additional osteoblastic bone lesion was found in the left ischial bone. A prostate biopsy was performed, and adenocarcinoma was confirmed. Decompression surgery of the L3 vertebra was conducted, and the pathologic result indicated that the lesion was a plasma cell neoplasm. Immunofixation electrophoresis showed the presence of biclonal gammopathy (IgG kappa and IgA lambda). Bone marrow plasma cells (CD138 positive cells) comprised 7.2% of nucleated cells and showed kappa positivity. We started radiation therapy for the L3 vertebra lesion, with a total dose of 3,940 cGy, and androgen deprivation therapy as treatment for the prostate cancer. The Korean Society for Laboratory Medicine 2011-10 2011-10-03 /pmc/articles/PMC3190009/ /pubmed/22016684 http://dx.doi.org/10.3343/kjlm.2011.31.4.285 Text en Copyright © 2011 The Korean Society for Laboratory Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Nae Yu
Gong, Soo Jung
Kim, Jimyung
Youn, Seon Min
Lee, Jung-Ae
Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title_full Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title_fullStr Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title_full_unstemmed Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title_short Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer
title_sort multiple myeloma with biclonal gammopathy accompanied by prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190009/
https://www.ncbi.nlm.nih.gov/pubmed/22016684
http://dx.doi.org/10.3343/kjlm.2011.31.4.285
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