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Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
PURPOSE: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency viru...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191113/ https://www.ncbi.nlm.nih.gov/pubmed/22003307 http://dx.doi.org/10.2147/CLEP.S24668 |
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author | Nanta, Sirisak Kantipong, Patcharee Pathipvanich, Panita Ruengorn, Chidchanok Tawichasri, Chamaiporn Patumanond, Jayanton |
author_facet | Nanta, Sirisak Kantipong, Patcharee Pathipvanich, Panita Ruengorn, Chidchanok Tawichasri, Chamaiporn Patumanond, Jayanton |
author_sort | Nanta, Sirisak |
collection | PubMed |
description | PURPOSE: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency virus (HIV) patients as well as in subgroups of HIV patients classified by clinical risk scores. PATIENTS AND METHODS: An extended cross-sectional study was conducted at a community hospital in Chiang Rai and a general hospital in Lampang. HIV patients registered between April 2009 and May 2010 were screened by a locally made ICT-TB test, including 38, 16, and 6 kD Microbacterium tuberculosis antigens, as well as by routine evaluations for TB diagnosis. Demographic data, medical history, signs, and symptoms were recorded. Participants were followed up for 2 months for final ascertainment of TB diagnosis. RESULTS: Of 206 patients, 37 (18%) had TB. Four clinical predictors were identified: low body mass index (<19 kg/m(2)), prolonged cough (duration >2 weeks), shaking chills (≥1 week), and no use of antiretrovirals. The area under the receiver operating curve was 90.2%; adding the ICT-TB test result increased the area nonsignificantly to 91.6% (P = 0.40). When patients were categorized by risk scores derived from selected clinical predictors into low (scores ≤7) and high (scores >7) TB risk groups, a positive ICT-TB test increased the positive predictive value nonsignificantly in the low risk group (from 12.5% to 27.3%, P = 0.17) and the high risk group (from 78.6% to 80.8%, P = 0.73). CONCLUSION: In this study setting, the ICT-TB test did not enhance TB diagnosis over the four clinical predictors in the overall group or any subgroups of HIV patients classified by clinical risk scores. |
format | Online Article Text |
id | pubmed-3191113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31911132011-10-14 Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients Nanta, Sirisak Kantipong, Patcharee Pathipvanich, Panita Ruengorn, Chidchanok Tawichasri, Chamaiporn Patumanond, Jayanton Clin Epidemiol Original Research PURPOSE: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency virus (HIV) patients as well as in subgroups of HIV patients classified by clinical risk scores. PATIENTS AND METHODS: An extended cross-sectional study was conducted at a community hospital in Chiang Rai and a general hospital in Lampang. HIV patients registered between April 2009 and May 2010 were screened by a locally made ICT-TB test, including 38, 16, and 6 kD Microbacterium tuberculosis antigens, as well as by routine evaluations for TB diagnosis. Demographic data, medical history, signs, and symptoms were recorded. Participants were followed up for 2 months for final ascertainment of TB diagnosis. RESULTS: Of 206 patients, 37 (18%) had TB. Four clinical predictors were identified: low body mass index (<19 kg/m(2)), prolonged cough (duration >2 weeks), shaking chills (≥1 week), and no use of antiretrovirals. The area under the receiver operating curve was 90.2%; adding the ICT-TB test result increased the area nonsignificantly to 91.6% (P = 0.40). When patients were categorized by risk scores derived from selected clinical predictors into low (scores ≤7) and high (scores >7) TB risk groups, a positive ICT-TB test increased the positive predictive value nonsignificantly in the low risk group (from 12.5% to 27.3%, P = 0.17) and the high risk group (from 78.6% to 80.8%, P = 0.73). CONCLUSION: In this study setting, the ICT-TB test did not enhance TB diagnosis over the four clinical predictors in the overall group or any subgroups of HIV patients classified by clinical risk scores. Dove Medical Press 2011-09-12 /pmc/articles/PMC3191113/ /pubmed/22003307 http://dx.doi.org/10.2147/CLEP.S24668 Text en © 2011 Nanta et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Nanta, Sirisak Kantipong, Patcharee Pathipvanich, Panita Ruengorn, Chidchanok Tawichasri, Chamaiporn Patumanond, Jayanton Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title | Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title_full | Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title_fullStr | Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title_full_unstemmed | Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title_short | Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients |
title_sort | diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in hiv patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191113/ https://www.ncbi.nlm.nih.gov/pubmed/22003307 http://dx.doi.org/10.2147/CLEP.S24668 |
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