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NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699

The stress inducible transcription factor, NF-κB induces genes involved in proliferation and apoptosis. Aberrant NF-κB activity is common in cancer and contributes to therapeutic-resistance. Poly(ADP-ribose) polymerase-1 (PARP-1) is activated during DNA strand break repair and is a known transcripti...

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Detalles Bibliográficos
Autores principales:	Hunter, Jill E., Willmore, Elaine, Irving, Julie A. E., Hostomsky, Zdenek, Veuger, Stephany J., Durkacz, Barbara W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191117/ https://www.ncbi.nlm.nih.gov/pubmed/21706052 http://dx.doi.org/10.1038/onc.2011.229

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