Humanizing π-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

BACKGROUND: Glutathione S-transferases (GSTs) metabolize drugs and xenobiotics. Yet despite high protein sequence homology, expression of π-class GSTs, the most abundant of the enzymes, varies significantly between species. In mouse liver, hepatocytes exhibit high mGstp expression, while in human li...

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Detalles Bibliográficos
Autores principales: Vaughn, Matthew P., Biswal Shinohara, Debika, Castagna, Nicole, Hicks, Jessica L., Netto, George, De Marzo, Angelo M., Speed, Traci J., Reichert, Zachery R., Kwabi-Addo, Bernard, Henderson, Colin J., Wolf, C. Roland, Yegnasubramanian, Srinivasan, Nelson, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191143/
https://www.ncbi.nlm.nih.gov/pubmed/22022436
http://dx.doi.org/10.1371/journal.pone.0025707

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