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Augmented Atherogenesis in LDL Receptor Deficient Mice Lacking Both Macrophage ABCA1 and ApoE

AIM: ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo) A-I. In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the co...

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Detalles Bibliográficos
Autores principales:	Lammers, Bart, Zhao, Ying, Hoekstra, Menno, Hildebrand, Reeni B., Ye, Dan, Meurs, Illiana, Van Berkel, Theo J. C., Van Eck, Miranda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191178/ https://www.ncbi.nlm.nih.gov/pubmed/22022523 http://dx.doi.org/10.1371/journal.pone.0026095

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