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Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)

INTRODUCTION: Cardiovascular disease (CVD) prevention guidelines recommend lifetime risk stratification for primary prevention of CVD, but no such risk stratification has been performed in India to date. METHODS: The authors estimated short-term and lifetime predicted CVD risk among 10 054 disease-f...

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Autores principales: Jeemon, Panniyammakal, Prabhakaran, Dorairaj, Huffman, Mark D, Ramakrishnan, Lakshmy, Goenka, Shifalika, Thankappan, K R, Mohan, V, Joshi, Prashant P, Mohan, B V M, Ahmed, F, Ramanathan, Meera, Ahuja, R, Chaturvedi, Vivek, Lloyd-Jones, Donald M, Reddy, K Srinath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191418/
https://www.ncbi.nlm.nih.gov/pubmed/22021747
http://dx.doi.org/10.1136/bmjopen-2011-000068
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author Jeemon, Panniyammakal
Prabhakaran, Dorairaj
Huffman, Mark D
Ramakrishnan, Lakshmy
Goenka, Shifalika
Thankappan, K R
Mohan, V
Joshi, Prashant P
Mohan, B V M
Ahmed, F
Ramanathan, Meera
Ahuja, R
Chaturvedi, Vivek
Lloyd-Jones, Donald M
Reddy, K Srinath
author_facet Jeemon, Panniyammakal
Prabhakaran, Dorairaj
Huffman, Mark D
Ramakrishnan, Lakshmy
Goenka, Shifalika
Thankappan, K R
Mohan, V
Joshi, Prashant P
Mohan, B V M
Ahmed, F
Ramanathan, Meera
Ahuja, R
Chaturvedi, Vivek
Lloyd-Jones, Donald M
Reddy, K Srinath
author_sort Jeemon, Panniyammakal
collection PubMed
description INTRODUCTION: Cardiovascular disease (CVD) prevention guidelines recommend lifetime risk stratification for primary prevention of CVD, but no such risk stratification has been performed in India to date. METHODS: The authors estimated short-term and lifetime predicted CVD risk among 10 054 disease-free, adult Indians in the 20–69-year age group who participated in a nationwide risk factor surveillance study. The study population was then stratified into high short-term (≥10% 10-year risk or diabetes), low short-term (<10%)/high lifetime and low short-term/low lifetime CVD risk groups. RESULTS: The mean age (SD) of the study population (men=63%) was 40.8±10.9 years. High short-term risk for coronary heart disease was prevalent in more than one-fifth of the population (23.5%, 95% CI 22.7 to 24.4). Nearly half of individuals with low short-term predicted risk (48.2%, 95% CI 47.1 to 49.3) had a high predicted lifetime risk for CVD. While the proportion of individuals with all optimal risk factors was 15.3% (95% CI 14.6% to 16.0%), it was 20.6% (95% CI 18.7% to 22.6%) and 8.8% (95% CI 7.7% to 10.5%) in the highest and lowest educational groups, respectively. CONCLUSION: Approximately one in two men and three in four women in India had low short-term predicted risks for CVD in this national study, based on aggregate risk factor burden. However, two in three men and one in two women had high lifetime predicted risks for CVD, highlighting a key limitation of short-term risk stratification.
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spelling pubmed-31914182011-10-13 Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results) Jeemon, Panniyammakal Prabhakaran, Dorairaj Huffman, Mark D Ramakrishnan, Lakshmy Goenka, Shifalika Thankappan, K R Mohan, V Joshi, Prashant P Mohan, B V M Ahmed, F Ramanathan, Meera Ahuja, R Chaturvedi, Vivek Lloyd-Jones, Donald M Reddy, K Srinath BMJ Open Epidemiology INTRODUCTION: Cardiovascular disease (CVD) prevention guidelines recommend lifetime risk stratification for primary prevention of CVD, but no such risk stratification has been performed in India to date. METHODS: The authors estimated short-term and lifetime predicted CVD risk among 10 054 disease-free, adult Indians in the 20–69-year age group who participated in a nationwide risk factor surveillance study. The study population was then stratified into high short-term (≥10% 10-year risk or diabetes), low short-term (<10%)/high lifetime and low short-term/low lifetime CVD risk groups. RESULTS: The mean age (SD) of the study population (men=63%) was 40.8±10.9 years. High short-term risk for coronary heart disease was prevalent in more than one-fifth of the population (23.5%, 95% CI 22.7 to 24.4). Nearly half of individuals with low short-term predicted risk (48.2%, 95% CI 47.1 to 49.3) had a high predicted lifetime risk for CVD. While the proportion of individuals with all optimal risk factors was 15.3% (95% CI 14.6% to 16.0%), it was 20.6% (95% CI 18.7% to 22.6%) and 8.8% (95% CI 7.7% to 10.5%) in the highest and lowest educational groups, respectively. CONCLUSION: Approximately one in two men and three in four women in India had low short-term predicted risks for CVD in this national study, based on aggregate risk factor burden. However, two in three men and one in two women had high lifetime predicted risks for CVD, highlighting a key limitation of short-term risk stratification. BMJ Group 2011-04-29 /pmc/articles/PMC3191418/ /pubmed/22021747 http://dx.doi.org/10.1136/bmjopen-2011-000068 Text en © 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Epidemiology
Jeemon, Panniyammakal
Prabhakaran, Dorairaj
Huffman, Mark D
Ramakrishnan, Lakshmy
Goenka, Shifalika
Thankappan, K R
Mohan, V
Joshi, Prashant P
Mohan, B V M
Ahmed, F
Ramanathan, Meera
Ahuja, R
Chaturvedi, Vivek
Lloyd-Jones, Donald M
Reddy, K Srinath
Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title_full Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title_fullStr Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title_full_unstemmed Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title_short Distribution of 10-year and lifetime predicted risk for cardiovascular disease in the Indian Sentinel Surveillance Study population (cross-sectional survey results)
title_sort distribution of 10-year and lifetime predicted risk for cardiovascular disease in the indian sentinel surveillance study population (cross-sectional survey results)
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191418/
https://www.ncbi.nlm.nih.gov/pubmed/22021747
http://dx.doi.org/10.1136/bmjopen-2011-000068
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