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A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers
OBJECTIVES: To study possible effects of aerosol exposure on lung function, fractional exhaled nitric oxide (FeNO) and inflammatory markers in blood from Norwegian cement production workers across one work shift (0 to 8 h) and again 32 h after the non-exposed baseline registration. METHODS: 95 worke...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191466/ https://www.ncbi.nlm.nih.gov/pubmed/21297153 http://dx.doi.org/10.1136/oem.2010.057729 |
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author | Fell, Anne Kristin M Notø, Hilde Skogstad, Marit Nordby, Karl-Christian Eduard, Wijnand Svendsen, Martin Veel Øvstebø, Reidun Trøseid, Anne Marie Siebke Kongerud, Johny |
author_facet | Fell, Anne Kristin M Notø, Hilde Skogstad, Marit Nordby, Karl-Christian Eduard, Wijnand Svendsen, Martin Veel Øvstebø, Reidun Trøseid, Anne Marie Siebke Kongerud, Johny |
author_sort | Fell, Anne Kristin M |
collection | PubMed |
description | OBJECTIVES: To study possible effects of aerosol exposure on lung function, fractional exhaled nitric oxide (FeNO) and inflammatory markers in blood from Norwegian cement production workers across one work shift (0 to 8 h) and again 32 h after the non-exposed baseline registration. METHODS: 95 workers from two cement plants in Norway were included. Assessment of lung function included spirometry and gas diffusion pre- and post-shift (0 and 8 h). FeNO concentrations were measured and blood samples collected at 0, 8 and 32 h. Blood analysis included cell counts of leucocytes and mediators of inflammation. RESULTS: The median respirable aerosol level was 0.3 mg/m(3) (range 0.02–6.2 mg/m(3)). FEV(1), FEF(25–75%) and DL(CO) decreased by 37 ml (p=0.04), 170 ml/s (p<0.001) and 0.17 mmol/min/kPa (p=0.02), respectively, across the shift. A 2 ppm reduction in FeNO between 0 and 32 h was detected (p=0.01). The number of leucocytes increased by 0.6×10(9) cells/l (p<0.001) across the shift, while fibrinogen levels increased by 0.02 g/l (p<0.001) from 0 to 32 h. TNF-α level increased and IL-10 decreased across the shift. Baseline levels of fibrinogen were associated with the highest level of respirable dust, and increased by 0.39 g/l (95% CI 0.06 to 0.72). CONCLUSIONS: We observed small cross-shift changes in lung function and inflammatory markers among cement production workers, indicating that inflammatory effects may occur at exposure levels well below 1 mg/m(3). However, because the associations between these acute changes and personal exposure measurements were weak and as the long-term consequences are unknown, these findings should be tested in a follow-up study. |
format | Online Article Text |
id | pubmed-3191466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-31914662011-10-13 A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers Fell, Anne Kristin M Notø, Hilde Skogstad, Marit Nordby, Karl-Christian Eduard, Wijnand Svendsen, Martin Veel Øvstebø, Reidun Trøseid, Anne Marie Siebke Kongerud, Johny Occup Environ Med Workplace OBJECTIVES: To study possible effects of aerosol exposure on lung function, fractional exhaled nitric oxide (FeNO) and inflammatory markers in blood from Norwegian cement production workers across one work shift (0 to 8 h) and again 32 h after the non-exposed baseline registration. METHODS: 95 workers from two cement plants in Norway were included. Assessment of lung function included spirometry and gas diffusion pre- and post-shift (0 and 8 h). FeNO concentrations were measured and blood samples collected at 0, 8 and 32 h. Blood analysis included cell counts of leucocytes and mediators of inflammation. RESULTS: The median respirable aerosol level was 0.3 mg/m(3) (range 0.02–6.2 mg/m(3)). FEV(1), FEF(25–75%) and DL(CO) decreased by 37 ml (p=0.04), 170 ml/s (p<0.001) and 0.17 mmol/min/kPa (p=0.02), respectively, across the shift. A 2 ppm reduction in FeNO between 0 and 32 h was detected (p=0.01). The number of leucocytes increased by 0.6×10(9) cells/l (p<0.001) across the shift, while fibrinogen levels increased by 0.02 g/l (p<0.001) from 0 to 32 h. TNF-α level increased and IL-10 decreased across the shift. Baseline levels of fibrinogen were associated with the highest level of respirable dust, and increased by 0.39 g/l (95% CI 0.06 to 0.72). CONCLUSIONS: We observed small cross-shift changes in lung function and inflammatory markers among cement production workers, indicating that inflammatory effects may occur at exposure levels well below 1 mg/m(3). However, because the associations between these acute changes and personal exposure measurements were weak and as the long-term consequences are unknown, these findings should be tested in a follow-up study. BMJ Group 2011-02-05 2011-11 /pmc/articles/PMC3191466/ /pubmed/21297153 http://dx.doi.org/10.1136/oem.2010.057729 Text en © 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Workplace Fell, Anne Kristin M Notø, Hilde Skogstad, Marit Nordby, Karl-Christian Eduard, Wijnand Svendsen, Martin Veel Øvstebø, Reidun Trøseid, Anne Marie Siebke Kongerud, Johny A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title | A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title_full | A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title_fullStr | A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title_full_unstemmed | A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title_short | A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers |
title_sort | cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in norwegian cement production workers |
topic | Workplace |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191466/ https://www.ncbi.nlm.nih.gov/pubmed/21297153 http://dx.doi.org/10.1136/oem.2010.057729 |
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