A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

BACKGROUND: Overexpression of mutant copper/zinc superoxide dismutase (SOD1) in rodents has provided useful models for studying the pathogenesis of amyotrophic lateral sclerosis (ALS). Microglia have been shown to contribute to ALS disease progression in these models, although the mechanism of this...

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Detalles Bibliográficos
Autores principales: Sargsyan, Siranush A, Blackburn, Daniel J, Barber, Siân C, Grosskreutz, Julian, De Vos, Kurt J, Monk, Peter N, Shaw, Pamela J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191510/
https://www.ncbi.nlm.nih.gov/pubmed/21943126
http://dx.doi.org/10.1186/1471-2202-12-91

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