E-Cadherin/β-Catenin Complex and the Epithelial Barrier

E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and d...

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Detalles Bibliográficos
Autores principales: Tian, Xinrui, Liu, Zhuola, Niu, Bo, Zhang, Jianlin, Tan, Thian Kui, Lee, So Ra, Zhao, Ye, Harris, David C. H., Zheng, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191826/
https://www.ncbi.nlm.nih.gov/pubmed/22007144
http://dx.doi.org/10.1155/2011/567305
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author Tian, Xinrui
Liu, Zhuola
Niu, Bo
Zhang, Jianlin
Tan, Thian Kui
Lee, So Ra
Zhao, Ye
Harris, David C. H.
Zheng, Guoping
author_facet Tian, Xinrui
Liu, Zhuola
Niu, Bo
Zhang, Jianlin
Tan, Thian Kui
Lee, So Ra
Zhao, Ye
Harris, David C. H.
Zheng, Guoping
author_sort Tian, Xinrui
collection PubMed
description E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
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spelling pubmed-31918262011-10-17 E-Cadherin/β-Catenin Complex and the Epithelial Barrier Tian, Xinrui Liu, Zhuola Niu, Bo Zhang, Jianlin Tan, Thian Kui Lee, So Ra Zhao, Ye Harris, David C. H. Zheng, Guoping J Biomed Biotechnol Review Article E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin. Hindawi Publishing Corporation 2011 2011-10-11 /pmc/articles/PMC3191826/ /pubmed/22007144 http://dx.doi.org/10.1155/2011/567305 Text en Copyright © 2011 Xinrui Tian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tian, Xinrui
Liu, Zhuola
Niu, Bo
Zhang, Jianlin
Tan, Thian Kui
Lee, So Ra
Zhao, Ye
Harris, David C. H.
Zheng, Guoping
E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title_full E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title_fullStr E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title_full_unstemmed E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title_short E-Cadherin/β-Catenin Complex and the Epithelial Barrier
title_sort e-cadherin/β-catenin complex and the epithelial barrier
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191826/
https://www.ncbi.nlm.nih.gov/pubmed/22007144
http://dx.doi.org/10.1155/2011/567305
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