Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of...

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Detalles Bibliográficos
Autores principales: Pidasheva, Svetlana, Trifari, Sara, Phillips, Anne, Hackney, Jason A., Ma, Yan, Smith, Ashley, Sohn, Sue J., Spits, Hergen, Little, Randall D., Behrens, Timothy W., Honigberg, Lee, Ghilardi, Nico, Clark, Hilary F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192060/
https://www.ncbi.nlm.nih.gov/pubmed/22022372
http://dx.doi.org/10.1371/journal.pone.0025038

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