EP4 receptor stimulation down-regulates human eosinophil function

Accumulation of eosinophils in tissue is a hallmark of allergic inflammation. Here we observed that a selective agonist of the PGE(2) receptor EP4, ONO AE1-329, potently attenuated the chemotaxis of human peripheral blood eosinophils, upregulation of the adhesion molecule CD11b and the production of...

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Detalles Bibliográficos
Autores principales: Luschnig-Schratl, Petra, Sturm, Eva M., Konya, Viktoria, Philipose, Sonia, Marsche, Gunther, Fröhlich, Eleonore, Samberger, Claudia, Lang-Loidolt, Doris, Gattenlöhner, Stefan, Lippe, Irmgard Th., Peskar, Bernhard A., Schuligoi, Rufina, Heinemann, Akos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192285/
https://www.ncbi.nlm.nih.gov/pubmed/21365278
http://dx.doi.org/10.1007/s00018-011-0642-5

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