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Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development
Integrase (IN) is a retroviral enzyme that catalyzes the insertion of viral DNA (vDNA) into host chromosomal DNA, which is necessary for efficient viral replication. The crystal structure of prototype foamy virus IN bound to cognate vDNA ends, a complex referred to as the intasome, has recently been...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192317/ https://www.ncbi.nlm.nih.gov/pubmed/22016749 http://dx.doi.org/10.3389/fmicb.2011.00210 |