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Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)

PURPOSE: We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM). PATIENTS AND METHODS: Between January 1991 and January 2010, 40 patients with ONSM were treated using FSRT. Of these, 19 patients received ra...

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Autores principales: Adeberg, Sebastian, Welzel, Thomas, Rieken, Stefan, Debus, Jürgen, Combs, Stephanie E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192676/
https://www.ncbi.nlm.nih.gov/pubmed/21923947
http://dx.doi.org/10.1186/1748-717X-6-117
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author Adeberg, Sebastian
Welzel, Thomas
Rieken, Stefan
Debus, Jürgen
Combs, Stephanie E
author_facet Adeberg, Sebastian
Welzel, Thomas
Rieken, Stefan
Debus, Jürgen
Combs, Stephanie E
author_sort Adeberg, Sebastian
collection PubMed
description PURPOSE: We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM). PATIENTS AND METHODS: Between January 1991 and January 2010, 40 patients with ONSM were treated using FSRT. Of these, 19 patients received radiotherapy as primary treatment, and 21 patients were treated after surgical resection. The median target volume was 9.2 ml, median total dose was 54 Gy in median single fractions of 1,8 Gy. RESULTS: Local progression-free survival was 100%. Median survival after FSRT was 60 months (range 4-228 months). In all patients overall toleration of FSRT was very good. Acute toxicity was mild. Prior to RT, 29 patients complained about any kind of visual impairment including visual field deficits, diplopia or amaurosis. Prior surgical resection was identified as a negative prognostic factor for visual outcome, whereas patients with larger tumor volumes demonstrated a higher number of patients with improvement of pre-existing visual deficits. CONCLUSION: Long-term outcome after FSRT for ONSM shows improved vision in patients not treated surgically prior to RT; moreover, the best improvement of visual deficits are observed in patients with larger target volumes. The absence of tumor recurrences supports that FSRT is a strong alternative to surgical resection especially in small tumors without extensive compression of normal tissue structures
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spelling pubmed-31926762011-10-14 Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) Adeberg, Sebastian Welzel, Thomas Rieken, Stefan Debus, Jürgen Combs, Stephanie E Radiat Oncol Research PURPOSE: We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM). PATIENTS AND METHODS: Between January 1991 and January 2010, 40 patients with ONSM were treated using FSRT. Of these, 19 patients received radiotherapy as primary treatment, and 21 patients were treated after surgical resection. The median target volume was 9.2 ml, median total dose was 54 Gy in median single fractions of 1,8 Gy. RESULTS: Local progression-free survival was 100%. Median survival after FSRT was 60 months (range 4-228 months). In all patients overall toleration of FSRT was very good. Acute toxicity was mild. Prior to RT, 29 patients complained about any kind of visual impairment including visual field deficits, diplopia or amaurosis. Prior surgical resection was identified as a negative prognostic factor for visual outcome, whereas patients with larger tumor volumes demonstrated a higher number of patients with improvement of pre-existing visual deficits. CONCLUSION: Long-term outcome after FSRT for ONSM shows improved vision in patients not treated surgically prior to RT; moreover, the best improvement of visual deficits are observed in patients with larger target volumes. The absence of tumor recurrences supports that FSRT is a strong alternative to surgical resection especially in small tumors without extensive compression of normal tissue structures BioMed Central 2011-09-18 /pmc/articles/PMC3192676/ /pubmed/21923947 http://dx.doi.org/10.1186/1748-717X-6-117 Text en Copyright ©2011 Adeberg et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Adeberg, Sebastian
Welzel, Thomas
Rieken, Stefan
Debus, Jürgen
Combs, Stephanie E
Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title_full Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title_fullStr Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title_full_unstemmed Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title_short Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
title_sort prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (onsm)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192676/
https://www.ncbi.nlm.nih.gov/pubmed/21923947
http://dx.doi.org/10.1186/1748-717X-6-117
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