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Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain

BACKGROUND: Convection-enhanced delivery (CED) of adenoviruses offers the potential of widespread virus distribution in the brain. In CED, the volume of distribution (Vd) should be related to the volume of infusion (Vi) and not to dose, but when using adenoviruses contrasting results have been repor...

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Detalles Bibliográficos
Autores principales:	Idema, Sander, Caretti, Viola, Lamfers, Martine L. M., van Beusechem, Victor W., Noske, David P., Vandertop, W. Peter, Dirven, Clemens M. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192704/ https://www.ncbi.nlm.nih.gov/pubmed/22022354 http://dx.doi.org/10.1371/journal.pone.0024396

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