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Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation
BACKGROUND: The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, i...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192765/ https://www.ncbi.nlm.nih.gov/pubmed/22022427 http://dx.doi.org/10.1371/journal.pone.0025645 |