Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

BACKGROUND: Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV. FINDINGS: We observed that the...

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Autores principales: Ravichandran, Veerasamy, Major, Eugen O, Ibe, Carol, Monaco, Maria Chiara, Girisetty, Mohan Kumar Haleyur, Hewlett, Indira K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192781/
https://www.ncbi.nlm.nih.gov/pubmed/21933387
http://dx.doi.org/10.1186/1743-422X-8-443
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author Ravichandran, Veerasamy
Major, Eugen O
Ibe, Carol
Monaco, Maria Chiara
Girisetty, Mohan Kumar Haleyur
Hewlett, Indira K
author_facet Ravichandran, Veerasamy
Major, Eugen O
Ibe, Carol
Monaco, Maria Chiara
Girisetty, Mohan Kumar Haleyur
Hewlett, Indira K
author_sort Ravichandran, Veerasamy
collection PubMed
description BACKGROUND: Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV. FINDINGS: We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells. CONCLUSIONS: These data suggest that neuronal cells are susceptible for XMRV infection.
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spelling pubmed-31927812011-10-14 Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection Ravichandran, Veerasamy Major, Eugen O Ibe, Carol Monaco, Maria Chiara Girisetty, Mohan Kumar Haleyur Hewlett, Indira K Virol J Short Report BACKGROUND: Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV. FINDINGS: We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells. CONCLUSIONS: These data suggest that neuronal cells are susceptible for XMRV infection. BioMed Central 2011-09-20 /pmc/articles/PMC3192781/ /pubmed/21933387 http://dx.doi.org/10.1186/1743-422X-8-443 Text en Copyright ©2011 Ravichandran et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Ravichandran, Veerasamy
Major, Eugen O
Ibe, Carol
Monaco, Maria Chiara
Girisetty, Mohan Kumar Haleyur
Hewlett, Indira K
Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title_full Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title_fullStr Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title_full_unstemmed Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title_short Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection
title_sort susceptibility of human primary neuronal cells to xenotropic murine leukemia virus-related (xmrv) virus infection
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192781/
https://www.ncbi.nlm.nih.gov/pubmed/21933387
http://dx.doi.org/10.1186/1743-422X-8-443
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