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Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer
Hormones, including estrogen and progesterone, and their receptors play an important role in the development and progression of ovarian carcinoma. Androgen, its receptor and coactivators have also been implicated in these processes. p44/Mep50/WDR77 was identified as a subunit of the methylosome comp...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192795/ https://www.ncbi.nlm.nih.gov/pubmed/22022581 http://dx.doi.org/10.1371/journal.pone.0026250 |
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author | Ligr, Martin Patwa, Ruzeen Rohintan Daniels, Garrett Pan, Lorraine Wu, Xinyu Li, Yirong Tian, Liantian Wang, Zhenxing Xu, Ruliang Wu, Jingjing Chen, Fan Liu, Jinsong Wei, Jian-Jun Lee, Peng |
author_facet | Ligr, Martin Patwa, Ruzeen Rohintan Daniels, Garrett Pan, Lorraine Wu, Xinyu Li, Yirong Tian, Liantian Wang, Zhenxing Xu, Ruliang Wu, Jingjing Chen, Fan Liu, Jinsong Wei, Jian-Jun Lee, Peng |
author_sort | Ligr, Martin |
collection | PubMed |
description | Hormones, including estrogen and progesterone, and their receptors play an important role in the development and progression of ovarian carcinoma. Androgen, its receptor and coactivators have also been implicated in these processes. p44/Mep50/WDR77 was identified as a subunit of the methylosome complex and lately characterized as a steroid receptor coactivator that enhances androgen receptor as well as estrogen receptor-mediated transcriptional activity in a ligand-dependent manner. We previously described distinct expression and function of p44 in prostate, testis, and breast cancers. In this report, we examined the expression and function of p44 in ovarian cancer. In contrast to findings in prostate and testicular cancer and similar to breast cancer, p44 shows strong cytoplasmic localization in morphologically normal ovarian surface and fallopian tube epithelia, while nuclear p44 is observed in invasive ovarian carcinoma. We observed that p44 can serve as a coactivator of both androgen receptor (AR) and estrogen receptor (ER) in ovarian cells. Further, overexpression of nuclear-localized p44 stimulates proliferation and invasion in ovarian cancer cells in the presence of estrogen or androgen. These findings strongly suggest that p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis. |
format | Online Article Text |
id | pubmed-3192795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31927952011-10-21 Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer Ligr, Martin Patwa, Ruzeen Rohintan Daniels, Garrett Pan, Lorraine Wu, Xinyu Li, Yirong Tian, Liantian Wang, Zhenxing Xu, Ruliang Wu, Jingjing Chen, Fan Liu, Jinsong Wei, Jian-Jun Lee, Peng PLoS One Research Article Hormones, including estrogen and progesterone, and their receptors play an important role in the development and progression of ovarian carcinoma. Androgen, its receptor and coactivators have also been implicated in these processes. p44/Mep50/WDR77 was identified as a subunit of the methylosome complex and lately characterized as a steroid receptor coactivator that enhances androgen receptor as well as estrogen receptor-mediated transcriptional activity in a ligand-dependent manner. We previously described distinct expression and function of p44 in prostate, testis, and breast cancers. In this report, we examined the expression and function of p44 in ovarian cancer. In contrast to findings in prostate and testicular cancer and similar to breast cancer, p44 shows strong cytoplasmic localization in morphologically normal ovarian surface and fallopian tube epithelia, while nuclear p44 is observed in invasive ovarian carcinoma. We observed that p44 can serve as a coactivator of both androgen receptor (AR) and estrogen receptor (ER) in ovarian cells. Further, overexpression of nuclear-localized p44 stimulates proliferation and invasion in ovarian cancer cells in the presence of estrogen or androgen. These findings strongly suggest that p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis. Public Library of Science 2011-10-13 /pmc/articles/PMC3192795/ /pubmed/22022581 http://dx.doi.org/10.1371/journal.pone.0026250 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Ligr, Martin Patwa, Ruzeen Rohintan Daniels, Garrett Pan, Lorraine Wu, Xinyu Li, Yirong Tian, Liantian Wang, Zhenxing Xu, Ruliang Wu, Jingjing Chen, Fan Liu, Jinsong Wei, Jian-Jun Lee, Peng Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title | Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title_full | Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title_fullStr | Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title_full_unstemmed | Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title_short | Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer |
title_sort | expression and function of androgen receptor coactivator p44/mep50/wdr77 in ovarian cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192795/ https://www.ncbi.nlm.nih.gov/pubmed/22022581 http://dx.doi.org/10.1371/journal.pone.0026250 |
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