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Large-Scale Conformational Changes of Trypanosoma cruzi Proline Racemase Predicted by Accelerated Molecular Dynamics Simulation

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11–18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline ra...

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Detalles Bibliográficos
Autores principales: de Oliveira, César Augusto F., Grant, Barry J., Zhou, Michelle, McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192803/
https://www.ncbi.nlm.nih.gov/pubmed/22022240
http://dx.doi.org/10.1371/journal.pcbi.1002178

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