Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques

Extensive experimental information supports the formation of ligand-specific conformations of G protein-coupled receptors (GPCRs) as a possible molecular basis for their functional selectivity for signaling pathways. Taking advantage of the recently published inactive and active crystal structures o...

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Detalles Bibliográficos
Autores principales: Provasi, Davide, Artacho, Marta Camacho, Negri, Ana, Mobarec, Juan Carlos, Filizola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192824/
https://www.ncbi.nlm.nih.gov/pubmed/22022248
http://dx.doi.org/10.1371/journal.pcbi.1002193

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