Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice

Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor. Here we show that the unfolded protein response (UPR), an ER protei...

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Detalles Bibliográficos
Autores principales: Yu, Zhigang, Wang, Adrienne M., Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Yue, Zhenyu, Robins, Diane M., Lieberman, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192827/
https://www.ncbi.nlm.nih.gov/pubmed/22022281
http://dx.doi.org/10.1371/journal.pgen.1002321

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