Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1) protects cells from oxidative stress via the base excision repair pathway and as a redox transcriptional coactivator. It is required for tumor progression/metastasis, and its up-regulation is associated with cancer resistance. Loss of APE1 e...

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Detalles Bibliográficos
Autores principales: Vascotto, Carlo, Bisetto, Elena, Li, Mengxia, Zeef, Leo A. H., D'Ambrosio, Chiara, Domenis, Rossana, Comelli, Marina, Delneri, Daniela, Scaloni, Andrea, Altieri, Fabio, Mavelli, Irene, Quadrifoglio, Franco, Kelley, Mark R., Tell, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192867/
https://www.ncbi.nlm.nih.gov/pubmed/21865600
http://dx.doi.org/10.1091/mbc.E11-05-0391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192867/
https://www.ncbi.nlm.nih.gov/pubmed/21865600
http://dx.doi.org/10.1091/mbc.E11-05-0391

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