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Prevention of estradiol 17β-d-glucuronide–induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes

In estradiol 17β-d-glucuronide (E17G)–induced cholestasis, the canalicular hepatocellular transporters bile salt export pump (Abcb11) and multidrug-resistance associated protein 2 (Abcc2) undergo endocytic internalization. cAMP stimulates the trafficking of transporter-containing vesicles to the api...

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Detalles Bibliográficos
Autores principales:	Zucchetti, Andrés E., Barosso, Ismael R., Boaglio, Andrea, Pellegrino, José M., Ochoa, Elena J., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192868/ https://www.ncbi.nlm.nih.gov/pubmed/21865596 http://dx.doi.org/10.1091/mbc.E11-01-0047

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