Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells

BACKGROUND: matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critical role in gastric cancer cell migration and proliferation. METHODS: In this st...

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Detalles Bibliográficos
Autores principales: Xu, Hao, Xu, Yong, Zhang, Wenjie, Shen, Lizong, Yang, Li, Xu, Zekuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193167/
https://www.ncbi.nlm.nih.gov/pubmed/21943213
http://dx.doi.org/10.1186/1756-9966-30-86
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author Xu, Hao
Xu, Yong
Zhang, Wenjie
Shen, Lizong
Yang, Li
Xu, Zekuan
author_facet Xu, Hao
Xu, Yong
Zhang, Wenjie
Shen, Lizong
Yang, Li
Xu, Zekuan
author_sort Xu, Hao
collection PubMed
description BACKGROUND: matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critical role in gastric cancer cell migration and proliferation. METHODS: In this study, AQP3 was silenced or over-expressed in SGC7901 cells. RESULTS: We found a significant decrease in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 knockdown, and a significant increase in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 over-expression in SGC7901 cells. We also found that AQP3 silence led to a significant decrease of phosphorylation of ser(473 )in AKT in SGC7901 cells. CONCLUSION: Our findings showed that AQP3 might positively regulate MMPs proteins expression through PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells.
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spelling pubmed-31931672011-10-15 Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells Xu, Hao Xu, Yong Zhang, Wenjie Shen, Lizong Yang, Li Xu, Zekuan J Exp Clin Cancer Res Research BACKGROUND: matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critical role in gastric cancer cell migration and proliferation. METHODS: In this study, AQP3 was silenced or over-expressed in SGC7901 cells. RESULTS: We found a significant decrease in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 knockdown, and a significant increase in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 over-expression in SGC7901 cells. We also found that AQP3 silence led to a significant decrease of phosphorylation of ser(473 )in AKT in SGC7901 cells. CONCLUSION: Our findings showed that AQP3 might positively regulate MMPs proteins expression through PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells. BioMed Central 2011-09-25 /pmc/articles/PMC3193167/ /pubmed/21943213 http://dx.doi.org/10.1186/1756-9966-30-86 Text en Copyright ©2011 Xu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xu, Hao
Xu, Yong
Zhang, Wenjie
Shen, Lizong
Yang, Li
Xu, Zekuan
Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title_full Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title_fullStr Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title_full_unstemmed Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title_short Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
title_sort aquaporin-3 positively regulates matrix metalloproteinases via pi3k/akt signal pathway in human gastric carcinoma sgc7901 cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193167/
https://www.ncbi.nlm.nih.gov/pubmed/21943213
http://dx.doi.org/10.1186/1756-9966-30-86
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