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Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease

The purpose of this study was to examine longitudinal change in gait and motor function in pre-manifest Huntington’s disease (HD). We examined ten pre-manifest subjects at baseline, one and five years. Quantitative gait data were collected with an electronic mat (GAITRite®). We analyzed measures rel...

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Autores principales: Rao, Ashwini K., Mazzoni, Pietro, Wasserman, Paula, Marder, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193287/
https://www.ncbi.nlm.nih.gov/pubmed/22008726
http://dx.doi.org/10.1371/currents.RRN1268
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author Rao, Ashwini K.
Mazzoni, Pietro
Wasserman, Paula
Marder, Karen
author_facet Rao, Ashwini K.
Mazzoni, Pietro
Wasserman, Paula
Marder, Karen
author_sort Rao, Ashwini K.
collection PubMed
description The purpose of this study was to examine longitudinal change in gait and motor function in pre-manifest Huntington’s disease (HD). We examined ten pre-manifest subjects at baseline, one and five years. Quantitative gait data were collected with an electronic mat (GAITRite®). We analyzed measures related to speed (velocity, step length, cadence), asymmetry (step length difference), dynamic balance (percent time in double support, support base) and variability in stride length and swing time. Motor function was assessed with the motor component of the Unified Huntington’s Disease Rating Scale. Gait velocity decreased (p=0.001), whereas step length difference (p=0.006), stride length variability (p=0.0001) and swing time variability increased (p=0.0001) from baseline to year five. Step length difference (p<0.05) and swing time variability (p<0.05) increased marginally in one year from baseline. UHDRS Total motor score increased over five years (p=0.003), though the increase in one year was not significant (p=0.053). Of the individual motor domain scores (eye, hand movements, gait and balance, chorea) only dystonia worsened over five years (p=0.02). Total motor score (r2= 0.49, p<0.001) and swing time variability (r2= 0.22, p<0.009) were correlated with estimated years to diagnosis. Our results present the longest longitudinal follow up of gait in pre-manifest HD thus far. Despite the small sample size, quantitative gait analysis was able to detect changes in gait speed, symmetry and variability. Swing time variability was particularly important because it increased in one year from baseline and was correlated with estimated time to diagnosis. Our results highlight the importance of predictive outcomes such as gait variability using quantitative analysis.
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spelling pubmed-31932872011-10-17 Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease Rao, Ashwini K. Mazzoni, Pietro Wasserman, Paula Marder, Karen PLoS Curr Huntington Disease The purpose of this study was to examine longitudinal change in gait and motor function in pre-manifest Huntington’s disease (HD). We examined ten pre-manifest subjects at baseline, one and five years. Quantitative gait data were collected with an electronic mat (GAITRite®). We analyzed measures related to speed (velocity, step length, cadence), asymmetry (step length difference), dynamic balance (percent time in double support, support base) and variability in stride length and swing time. Motor function was assessed with the motor component of the Unified Huntington’s Disease Rating Scale. Gait velocity decreased (p=0.001), whereas step length difference (p=0.006), stride length variability (p=0.0001) and swing time variability increased (p=0.0001) from baseline to year five. Step length difference (p<0.05) and swing time variability (p<0.05) increased marginally in one year from baseline. UHDRS Total motor score increased over five years (p=0.003), though the increase in one year was not significant (p=0.053). Of the individual motor domain scores (eye, hand movements, gait and balance, chorea) only dystonia worsened over five years (p=0.02). Total motor score (r2= 0.49, p<0.001) and swing time variability (r2= 0.22, p<0.009) were correlated with estimated years to diagnosis. Our results present the longest longitudinal follow up of gait in pre-manifest HD thus far. Despite the small sample size, quantitative gait analysis was able to detect changes in gait speed, symmetry and variability. Swing time variability was particularly important because it increased in one year from baseline and was correlated with estimated time to diagnosis. Our results highlight the importance of predictive outcomes such as gait variability using quantitative analysis. Public Library of Science 2011-10-04 /pmc/articles/PMC3193287/ /pubmed/22008726 http://dx.doi.org/10.1371/currents.RRN1268 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Huntington Disease
Rao, Ashwini K.
Mazzoni, Pietro
Wasserman, Paula
Marder, Karen
Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title_full Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title_fullStr Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title_full_unstemmed Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title_short Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington’s Disease
title_sort longitudinal change in gait and motor function in pre-manifest huntington’s disease
topic Huntington Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193287/
https://www.ncbi.nlm.nih.gov/pubmed/22008726
http://dx.doi.org/10.1371/currents.RRN1268
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