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Systematic generation of in vivo G protein-coupled receptor mutants in the rat
G-protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors that are involved in a wide range of physiological and pathological processes, and are targets for many therapeutic interventions. However, genetic models in the rat, one of the most widely used model organisms i...
Autores principales: | van Boxtel, R, Vroling, B, Toonen, P, Nijman, I J, van Roekel, H, Verheul, M, Baakman, C, Guryev, V, Vriend, G, Cuppen, E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194067/ https://www.ncbi.nlm.nih.gov/pubmed/20531371 http://dx.doi.org/10.1038/tpj.2010.44 |
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